Supplier of fully automated nanoparticle drug manufacturing system

Lipid nanoparticle drug manufacturing systemIt is a microfluidic device specially developed by Suzhou Aitson based on the process research and validation experiments of a large number of micro nano formulation microfluidic technology applications, which can be used for scientific research and early process validation and technology development. MPE-L2 is powered by an injection pump and can conduct experiments with fewer samples. In addition, the innovative design of MPE-L2 supports multiple injections during the experiment.

Functional Application

♦ Preparation of chemical drug liposomes, such as irinotecan liposomes;

♦ Preparation of biological lipid nanoparticles (LNP), such as mRNA liposomes, siRNA liposomes, etc;

♦ Preparation of polymer nanoparticles/microspheres, such as PLGA microspheres, PEG-PLGA nanoparticles, etc;

♦ Preparation of emulsions, such as vaccine adjuvants, fat emulsion preparations, etc;

♦ Organic/inorganic nanoparticles, such as gold nanoparticles;

♦ Other related micro nano formulations.

microfluidic chip

Microfluidic chips are customized special channel structure components based on application processes, whose channel structure and size are combined with project process requirements, and belong to customized structural components. Specifically, the following four functions can be achieved:

① Mixing and emulsification of two phases;

② Incubation after particle formation;

③ Particle size control after particle formation;

④ Secondary mixing or emulsification.

Typical chip

The Aitson microfluidic chip is based on microfluidic technology, combined with the preparation principles of micro nano formulations, and is specially designed and finely processed. Aitson metal microfluidic chips, with independent intellectual property rights, meet the application needs of linear amplification and continuous production of various types of micro nano formulations.

Lipid nanoparticle drug manufacturing systemTechnical Specifications:

Introduction to Microfluidic Control Backup System

The Aitson microfluidic control preparation system is positioned for scientific research and industrial technology applications of micro nano formulations and complex injections. Through microfluidic chips, highly integrated and systematic hardware systems (delivery pump systems, PAT toolkits, etc.), and process oriented humanized software systems, it provides mature and rich solutions for the scientific research and industrial applications of different drug carriers such as Liposomes, LNPs, microemulsions, microcrystals, microspheres, etc. Devices and solutions based on Aitson microfluidic technology have been used in the development of multiple clinical drugs.

Introduction to Microfluidic Technology

Microfluidic technology is a technique based on (micro) fluid mechanics theory that enables sample preparation and processing in pipelines. Combining the physical and chemical models of microfluidics with fluid mechanics theory can achieve functions such as mixing, emulsification, separation, and purification of samples.

Microfluidic technology combines Process Control Technology (PCT) with Process Analytical Technology (PAT) to achieve excellent Online Preparation Technology (OPT) for sample preparation. During the continuous preparation process, the parameters of the sample are controllable and have good reproducibility, making it more scalable compared to traditional stepwise and batch production methods.

The microfluidic control preparation instrument MPE-L2 can achieve functions such as initial emulsification, re emulsification, and particle size control of samples.

The microfluidic control preparation system is connected to the microfluidic chip through a preparation pump and a high-pressure delivery pump. Phase A and phase B can be delivered to the chip at a constant speed in a certain proportion for mixing and emulsification. By designing different flow channel structures and controlling different speeds in microfluidic chips, the sample can achieve turbulent, laminar, or atomized states in the microfluidic chip, which can meet the requirements of sample colostrum or re emulsification.

The prepared sample is transported to a high-pressure microfluidic chip through a high-pressure pump, and the particle size is controlled by impact and shear forces to achieve the desired range. The minimum particle size can reach within 100nm, and the PDI is below 0.1.