Supplier of Bioautomation DNA RNA Synthesis Instrument in the United States

Imported DNA RNA nucleic acid synthesizerDesign an automated instrument for synthesizing oligonucleotides structurally similar to DNA or RNA. Generally used in solid-phase synthesis, one nucleotide is added to the extended oligonucleotide chain each time, and each nucleotide is added using the same chemical reaction with the corresponding purine or pyrimidine base derivative. The chemical reactions and operational details used vary with different instruments, and the widely used method is the phosphoramide method for DNA synthesis.

OLIGOMAKER Industrial GradeImported DNA RNA nucleic acid synthesizerSpecially designed for customers who synthesize fewer oligonucleotide sequences, the 48 column model has a total of 48 synthesis columns, which can synthesize 48 products (20mer) in 2.5 hours at once. It can be configured with 6, 8, 10, 15 base bottle positions and can adapt to 1L, 2.5L or larger reagent bottles. The synthesis range is 10nmol-1umol. In addition to conventional synthesis, various special synthesis methods such as modification, fluorescent labeling, and thiolation can also be used to meet the different needs of customers. At the same time, the OLIGOMAKER 48 industrial grade DNA RNA nucleic acid synthesizer also supports rapid synthesis, which can quickly synthesize 10 products (20mer) within 2 hours.

Technical parameters of DNA RNA nucleic acid synthesizer:

(1) Number of synthetic columns: With 48 synthetic columns, it can simultaneously synthesize 48 types of oligonucleotides of the same or different lengths.

(2) Synthesis speed: 48 products (20mer) can be synthesized within 2.5 hours, and 10 products (20mer) can be synthesized within 2 hours

(3) Base bottle positions: 6 base bottle positions, can be upgraded to 8, 10, and can support up to 15 base bottle positions.

(4) Reagent bottle position: Supports 1 and 2.5L reagent bottles.

(5) Solvent consumption: There is no need to repeatedly rinse the reagent pipeline during the synthesis process, and the solvent consumption per cycle is less than 1ml.

(6) Types of Composite Columns: Supports pre filled columns and self filled columns.

(7) Composite column bearing method: disc type.

(8) Types of synthetic products: DNA, RNA, LNA, thio, modification, fluorescent labeling, etc.

Performance characteristics of DNA RNA nucleic acid synthesizer:

(1) Synthesis range: 10nmol, 50nmol, 200nmol, 1umol.

(2) Synthesis efficiency: Within the 10nmol synthesis range, the purified product can reach 2 OD; within the 50nmol synthesis range, the purified product can reach up to 5 OD.

(3) Synthetic product length: more than 100bp.

(4) Coupling rate: DNA ≥ 99%.

(5) Product compatibility: The same host is compatible with 48,96192 column composite disks. Purchasing the corresponding composite disk can upgrade to 96 column and 192 column.

The imported OligoMaker DNA RNA Primer Nucleic Acid Synthesis Instrument is a flexible and intelligent synthesis solution system. The same instrument can obtain different synthesis schemes, and customers can design their own nucleotide synthesis instrument scheme according to their specific laboratory requirements.

The standard configuration includes 6 standard base monomers，The instrument hardware is easy to operate, simply place the reaction plate in the instrument to start synthesis. Maintenance is simple and fast. Replacing pipes or valves is easy because they are placed in front of the instrument. Use standard 3900 type columns. The column can be an open column with loose CPG, or it can have bottom and top filters or a closed column.

In primer mode, you can independently trigger each monomer reagent while checking all reagent nozzles. Alternatively, you can use the touch screen to control the triggering of all monomer reagents.

If the valve malfunctions, excess reagents will be automatically discharged without damaging the instrument.

Passed CE certification and the noise level is below 70 decibels.

The inner packaging measures 65 x 55 x 55 cm, with a net weight of 55 kg; the outer packaging measures 80 x 60 x 75cm, with a weight of 90 kg.

The software includes a flexible synthesis protocol editor that allows operators to modify the included protocols and save them under a new name, or write protocols from scratch. Protocol editing can be completed in Excel. It is easy to edit special protocols for different synthesis scales and sequence lengths. For example, a specially extended coupling time can be given to slowly coupled base pairs. If necessary, additional coupling reaction time can be given to all monomers. The software is simple and easy to use. After creating running data in an Excel spreadsheet on a computer or tablet, it can be transferred to the instrument using a network connection such as Wi Fi or a standard USB drive. During the experiment, experimental data can be collected from the PC end to monitor the experimental results.

performance

OligoMaker X12 can synthesize 12 oligonucleotides of 20 pairs in parallel within 1 hour.

OligoMaker 48 can synthesize up to 48 oligonucleotides of 20 pairs in parallel within 2 hours.

OligoMaker 96 can synthesize up to 96 oligonucleotides of 20 pairs in parallel within 3 hours.

OligoMaker 192 can synthesize up to 192 oligonucleotides of 20 pairs in parallel within 4 hours. The imported OligoMaker DNA RNA Primer Nucleic Acid Synthesis Instrument can synthesize nucleotides in sizes of 10, 50, 200, and 1000 nmol under the IUPAC-IUB standard rules.

Two reaction disks, one disk can load and synthesize nucleotides, and the other disk is ready for purification steps.

OligoMaker 48 can be upgraded to OligoMaker 96 and OligoMaker 192;

OligoMaker 96 can be upgraded to OligoMaker 192.

Compliant with IUPAC-IUB standard rules

Automated deprotection base accessories

The equipment we provide can assist with the support of nucleotide deprotection automated instrument systems. All products are microporous plates made of anodized aluminum (these accessories are not included in the standard configuration).

OM-96-001-VM

OM-96-005-VM

OM-96-020-DP

RPC Purification Accessories

Devices for purification and reusable RPC columns (these accessories are not included in the standard configuration).

OM-96-002-RPC

OM-96-006-PRC

OM-96-010-RPC

OM-96-100-RPC